Mailshake vs Reply.io

Mailshake focuses on email-led campaigns; Reply.io adds AI to automate outreach. Pick Mailshake for lean budgets, Reply.io for AI-driven volume.

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The verdict Side by side Plans and pricing Who each is for Other options

The verdict

For most lean B2B founders, I'd start with Mailshake. It's the cheaper way onto a credible platform (29 USD/user/mo against 49 USD), it's email-led and deliverability-focused, and the single dashboard means you get a clean cold-email sequence live without configuring five channels you won't use yet.\n\nThe moment that flips is when reply volume or channel mix outgrows you. Reply.io spreads across email, LinkedIn, calls, SMS and WhatsApp, and its AI SDR drafts and handles replies, which is real leverage when there's no one but you reading the inbox. You pay more for that breadth, so buy it when you'll actually use it, not before. Start narrow, graduate when the volume earns it.

What the data says

Reply.io covers more of the features we compared: 6 of 6, against 5.
Mailshake starts lower, at $25/mo against $49/mo.
Only Reply.io has an MCP server, so an AI employee can work in it directly.
In our Outbound ranking, Reply.io places 4 and Mailshake 12 of 33.

Side by side

Mailshake and Reply.io compared
10 points compared	Mailshake	Reply.io
Starts at	$25/mo	$49/mo
Free plan	No	No
API	Yes	Yes
MCP server	No	Yes
AI reply handling	No	Yes
Built-in email warmup	Yes	Yes
Built-in lead database	Yes	Yes
Built-in outreach (sequences/dialer)	Yes	Yes
LinkedIn automation	Yes	Yes
Unified inbox	Yes	Yes
Links	Visit	Visit

Plans and pricing

Mailshake

Starter1 email address, 1,500 sends a month, unlimited contacts and campaigns. Annual shown as 25 per month.$29/mo/seat
Email Outreach2 email addresses, unlimited sends, rotation, unified inbox and CRM integrations. Annual shown as 45 per month.$49/mo/seat
Sales Engagement10 email addresses, unlimited sends and 5 phone numbers with a dialer. Annual shown as 85 per month.$99/mo/seat

Reply.io

Email VolumeFrom $49 per month billed annually for 1,000 active contacts; unlimited users and mailboxes; the monthly price scales with contacts.$588/yr
MultichannelPer user: $99 monthly or $89 per user per month billed annually; email, LinkedIn, calls and SMS.$99/mo/seat
Jason AI SDRFully automated AI SDR from $500 per month.$500/mo

Prices as the vendors list them. They change often; the final price is on their sites.

Who each is for

Choose Mailshake if…

Pick Reply.io if you're running genuinely multichannel outbound or you want AI to carry the reply load. It covers email, LinkedIn, calls, SMS and WhatsApp from one sequence builder, includes a B2B contact database and warmup, and its AI SDR (Jason) drafts and handles replies, which is the difference-maker when you have no SDR to triage responses. You'll pay more (~49 USD email, ~89 USD multichannel, higher again for the AI tier), so it earns its place once your channel mix and reply volume justify the spend.

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Choose Reply.io if…

Pick Mailshake if cold email is your core channel and you want the cheapest credible entry at 29 USD/user/mo. It suits a founder who wants one dashboard, strong deliverability tooling and email-led sequencing without the overhead of configuring SMS, WhatsApp and an AI SDR they won't touch yet. The built-in lead finder (Data Finder add-on from 19 USD/mo) and email warmup mean you can prospect and protect your sending reputation in one place. It's the lean, focused starting point.

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